Endocrine Abstracts

Objective: PCOS affects approximately 10% of women of reproductive age. We have audited the management of women attending the multidisciplinary PCOS clinic at the Royal Berkshire Hospital which was set up in September 2002.Methods: Data on women attending the PCOS clinic at the Royal Berkshire Hospital between September 2002 and September 2004 were analysed. Points investigated were: baseline characteristics, adequacy of investigations and efficacy of tr...

Significant delays in follow up and institution of thyroxine replacement for patients developing post-radioiodine (RAI) hypothyroidism were revealed by a three year retrospective audit. To reduce the incidence of undiagnosed early hypothyroidism and lengthy waits between outpatient visits, a telephone clinic was introduced in August 2000. Thyroid function tests are checked at 3, 6, 9 and 12 weeks post-treatment. Results are checked weekly by a Specialist Registrar. Patients wh...

The peptides, cocaine- and amphetamine-regulated transcript (CART), alpha-melanocyte-stimulating hormone (alpha-MSH) and glucagon-like peptide-1 (GLP-1) are present in the circulation and may act as peripheral anorectic signals. CART, alpha-MSH and GLP-1 may play a role in tumour anorexia, but their roles in anorexia nervosa (AN) are unknown. These studies aimed firstly to measure plasma CART, alpha-MSH and GLP-1 in control and AN subjects and secondly, to measure plasma CART ...

The hypothalamic peptide, cocaine and amphetamine regulated transcript (CART) was originally reported to act as an anorexigenic peptide. However, we have recently shown that CART injection into the hypothalamic arcuate nucleus (ARC), acutely stimulates food intake. Here, we characterise the role of arcuate nucleus CART in the long term regulation of food intake and brown adipose tissue (BAT) using i) repeated intra-arcuate injection of CART peptide [CART(55-102)] and ii) polye...